Inhibition of Cytochrome P450 by Carbon Monoxide: Relevance to Drug Resistance in Human Breast Cancer Therapy

Drug resistance to conventional chemotherapeutics is a great impediment cancer therapy. A major part of this problem arises from rapid metabolism the drugs by cytochrome P450 class enzymes before they reach their targets or at target itself. Inhibition such enzymatic deactivation could offer partial rescue and make chemotherapy more effective. Site specific delivery exogenous carbon monoxide has been shown inhibit resurrect sensitivity already available in market. Successful design for application CO will thus be extremely desirable patients particularly poor countries where antibody-based nanodrug therapies, discovered recently, are too expensive general population. The potential monoxide-induced inhibition improve drug sensitization breast therapy discussed account.